Work

Intact NKG2D-Independent Function of NK Cells Chronically Stimulated with the NKG2D Ligand Rae-1

Year: 2010

Type: article

Abstract: Human tumors frequently express membrane-bound or soluble NK group 2, member D (NKG2D) ligands. This results in chronic engagement of NKG2D on the surfaces of NK and CD8(+) T cells and rapid internalization of the receptor. Although it is well appreciated that this phenomenon impairs NKG2D-dependent function, careful analysis of NKG2D-independent functions in cells chronically stimulated through NKG2D is lacking. Using a mouse model of chronic NKG2D ligand expression, we show that constant exposure to NKG2D ligands does not functionally impair NK cells and CD8(+) T cells in the context of viral infection.

Source: The Journal of Immunology

DOI: 10.4049/jimmunol.1000397

Authors: Marine Champsaur, Joshua N Beilke, Kouetsu Ogasawara, Ulrich H Koszinowski, Stipan Jonjic, Lewis L Lanier

Institutions: University of California, San Francisco, Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, University of Rijeka

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, Japan Society for the Promotion of Science, National Cancer Institute, National Institute of Allergy and Infectious Diseases