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Dietary Fructose: Implications for Dysregulation of Energy Homeostasis and Lipid/Carbohydrate Metabolism

Year: 2005
Type: article
Abstract: Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity. Fructose does not increase insulin and leptin or suppress ghrelin, which suggests an endocrine mechanism by which it induces a positive energy balance. This review examines the available data on the effects of dietary fructose on energy homeostasis and lipid/carbohydrate metabolism. Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized.
DOI: 10.1111/j.1753-4887.2005.tb00132.x
Language: English
Field: Medicine
Open Access status: bronze
Funders: American Diabetes Association, U.S. Department of Agriculture, Dairy Management, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Fructose vs Glucose: Leptin, Appetite and Food Intake, G223716007, Dietary Fructose: Hormones & TG/Lipoprotein Metabolism, G366406518, G4076308108, Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia, G9000160578
OpenAlex ID: W2162627097
FWCI: 11.83
Cites: 224
Cited by: 609
Related to: 10