Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
Year: 2006
Type: review
Abstract: The indolocarbazole family of natural products, including the biosynthetically related bisindolylmaleimides, is reviewed (with 316 references cited). The isolation of indolocarbazoles from natural sources and the biosynthesis of this class of compounds are thoroughly reviewed, including recent developments in molecular genetics, enzymology and metabolic engineering. The biological activities and underlying modes of action displayed by natural and synthetic indolocarbazoles is also presented, with an emphasis on the development of analogs that have entered clinical trials for its future use against cancer or other diseases.
Source: Natural Product Reports
DOI: 10.1039/b601930g
Authors: César Sánchez, Carmen Méndez, José A. Salas
Institution: Universidad de Oviedo
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2162655337