Work

Siglec-G Expression on Donor T Cells Controls Severity of GVHD

Year: 2015

Type: article

Abstract: Members of the sialic acid binding Ig–like lectin (Siglec) family, such as Siglec-G, have immunoreceptor tyrosine-based inhibitory motifs (ITIM) regions that negatively regulate innate immune activation induced by non-infectious damage-associated molecular patterns (DAMPs). The T-cell autonomous role of Siglec-G in modulating immunity is not known. In order to examine the role of Siglec-G on T cells we utilized the well-established MHC disparate B6->BALB/c model of allogeneic BMT. BALB/c WT mice were lethally irradiated (850cGy) and transplanted on day 0 with 5x106 WT bone marrow from either syngeneic WT-BALB/c or allogeneic WT-B6 along with 0.5x106CD90+T cells from WT or Siglec-G-/- B6 animals.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.061