Clinical Relevance of Serum Sialic Acids Evaluation and Correlation With Haptoglobin and Serum Amyloid a in Diseased Cattle
Year: 2010
Type: article
Abstract: Summary Nazifi, S., M. Ansari-Lari, M. R. Tabandeh, K. Badiei, N. Ghafari, I. Karachi, A. Nowroozi-Asl & S. M. Razavi, 2010. Clinical relevance of serum sialic acids evaluation and correla-tion with haptoglobin and serum amyloid A in diseased cattle. Bulg. J. Vet. Med. , 13 , No 1, 45 −54. The present study was conducted to evaluate the concentrations of sialic acids and their correlation with acute phase proteins (haptoglobin and serum amyloid A) in various inflammatory disorders in cattle. Data were obtained from six dairy farms in Fars province, southern Iran. Forty cows with vari-ous inflammatory diseases were examined: acute local traumatic reticuloperitonitis (TRP) (6 cases), theileriosis due to Theileria annulata (11 cases), acute metritis (6 cases), colisepticaemia (6 cases), ephemeral fever (5 cases) and pneumonia (6 cases). Ten clinically healthy adult cattle were selected as control group. Serum haptoglobin (Hp), serum amyloid A (SAA), total sialic acid (TSA), lipid bound sialic acid (LBSA) and protein bound sialic acid (PBSA) were measured by validated standard methods. All studied variables were statistically significantly higher in diseased animals compared to healthy ones (P≤0.001); but the magnitude of increase was considerably different among various dise-ases. TSA, PBSA and LBSA showed relatively consistent changes in all diseases, however serum amyloid A and haptoglobin were more prominently increased in TRP and metritis. Results showed significant correlations between TSA and PBSA in healthy cattle, TRP and pneumonia groups. Sig-nificant correlations were also present between TSA and LBSA in TRP, pneumonia and metritis. No significant correlation was observed between haptoglobin and serum amyloid A as well as between either of these acute phase proteins and any other parameter.
Language: English
Topic: Animal health and immunology
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2162783510