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Complete Genome Sequence of Cell Culture-Attenuated Guinea Pig Cytomegalovirus Cloned as an Infectious Bacterial Artificial Chromosome

Year: 2014

Type: article

Abstract: The complete genome sequence of attenuated guinea pig cytomegalovirus cloned as bacterial artificial chromosome N13R10 was determined. Comparison to pathogenic salivary gland-derived virus revealed 13 differences, 1 of which disrupted overlapping open reading frames encoding GP129 and GP130. Attenuation of N13R10 may arise from an inability to express GP129 and/or GP130.

Source: Genome Announcements

DOI: 10.1128/genomea.00928-14

Authors: Dongmei Yang, Zohaib Alam, Xiaohong Cui, Michael Chen, Carly J. Sherrod, Michael A. McVoy, Mark R. Schleiss, Dirk P. Dittmer

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center, Virginia Commonwealth University, Virginia Commonwealth University Medical Center, University of Minnesota

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1178797104, G4373353908, Viral immunomodulation and rational CMV vaccine design, Viral Oncogenesis, Latency, and Replication

OpenAlex ID: W2162848934

FWCI: 1.123

Cites: 14

Cited by: 6

Related to: 10