Work

The oral‐systemic personalized medicine model at Marshfield Clinic

Year: 2012

Type: review

Abstract: Periodontal disease and diabetes, two diseases that have achieved epidemic status, share a bidirectional relationship driven by micro-inflammatory processes. The present review frames the current understanding of the pathological processes that appear to link these diseases and advances the hypothesis that reversal of the epidemic is possible through application of interdisciplinary intervention and advancement of oral-systemic personalized medicine. An overview of how Marshfield Clinic's unique clinical, informatics and bio-repository resources and infrastructures are being aligned to advance oral-systemic personalized medicine is presented as an interventional model with the potential to reverse the epidemic trends seen for these two chronic diseases over the past several decades. The overall vision is to engineer a transformational shift in paradigm from 'personalized medicine' to 'personalized health'.

Source: Oral Diseases

DOI: 10.1111/j.1601-0825.2012.01921.x

Authors: I Glurich, A Acharya, SK Shukla, GR Nycz, MH Brilliant

Institutions: Marshfield Clinic Research Foundation, Marshfield Clinic Research Institute, Marshfield Clinic, Marshfield Clinic

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Human Genome Research Institute, National Center for Research Resources, National Center for Advancing Translational Sciences