Work

Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin

Year: 2007

Type: article

Abstract: Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01542-07

Authors: Jason M. Cota, Jodi L. Grabinski, Robert L. Talbert, David S. Burgess, P. David Rogers, Thomas D. Edlind, Nathan P. Wiederhold

Institutions: The University of Texas at San Antonio Health Science Center, The University of Texas at Austin, University of Tennessee Health Science Center, Drexel University

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2162906973

FWCI: 2.757

Cites: 25

Cited by: 69

Related to: 10