Work

Chromatin disruption and modification

Year: 1999

Type: review

Abstract: Chromatin disruption and modification are associated with transcriptional regulation by diverse coactivators and corepressors. Here we discuss the possible structural basis and functional consequences of the observed alterations in chromatin associated with transcriptional activation and repression. Recent advances in defining the roles of individual histones and their domains in the assembly and maintenance of regulatory architectures provide a framework for understanding how chromatin remodelling machines, histone acetyltransferases and deacetylases function.

Source: Nucleic Acids Research

DOI: 10.1093/nar/27.3.711

Authors: A. P. Wolffe, J. J. Hayes

Institutions: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of Rochester Medicine, University of Rochester

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2163046373

FWCI: 4.833

Cites: 173

Cited by: 574

Related to: 8