Work

Higher Tacrolimus Concentrations Early Post-Transplant Reduce the Risk of Acute Graft-Versus-Host Disease in Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation

Year: 2015

Type: article

Abstract: Tacrolimus (TAC) remains the backbone of graft-versus-host disease (GVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (HSCT). There is significant variability in the serum concentrations of TAC attained early post-transplant due to drug interactions and genomic variation. Whether a relationship exists between early TAC concentrations and acute GVHD in reduced-intensity conditioning (RIC) HSCT remains poorly characterized.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.594