Work

Reprogramming of early embryonic blastomeres into endodermal progenitors by a Caenorhabditis elegans GATA factor

Year: 1998

Type: preprint

Abstract: The END-1 GATA factor has been implicated in specifying endoderm in Caenorhabditis elegans and is the earliest known zygotic protein expressed in the lineage of E, the clonal endoderm progenitor. We report that ubiquitous end-1 expression during a critical period in embryogenesis causes all non-endodermal lineages to produce endoderm instead of ectoderm and/or mesoderm. END-1 expression bypasses the requirement for maternal SKN-1 and the maternal Wnt signaling pathway in endoderm formation. This suggests that a primary function of these maternal factors is to regulate zygotic end-1 expression, which is then sufficient to initiate the entire program for endoderm development.

Source: Genes & Development

DOI: 10.1101/gad.12.24.3809

Authors: Jiangwen Zhu, Tetsunari Fukushige, James D. McGhee, Joel H. Rothman

Institutions: University of California, Santa Barbara, University of Calgary

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, March of Dimes Foundation, Fondation pour la Recherche Médicale, Medical Research Council Canada, National Institutes of Health, Medical Research Council, National Center for Research Resources

OpenAlex ID: W2163127276

Cites: 30

Cited by: 155

Related to: 10