Work

Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins

Year: 2006

Type: article

Abstract: Converging on the goal: New chemistry enables the key Cys-peptide-(αthioester) intermediate to be extended by ligation at either the N or C termini in a controlled fashion. This approach forms the basis for a set of novel tactics for the fully convergent synthesis of proteins by the chemical ligation of multiple peptide segments.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200600702

Authors: Duhee Bang, Brad L. Pentelute, Stephen B. H. Kent

Institution: University of Chicago

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: U.S. Department of Energy

Awards: G222768804, CHEMICAL METHODS FOR THE PRODUCTION OF PROTEINS, OF PROTEIN AND PEPTIDE REAGENTS, AND FOR THE CHARACTERIZATION OF PROTEIN COMPLEXES