Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire
Year: 2004
Type: article
Abstract: The human peripheral B-cell compartment displays a large population of immunoglobulin M-positive, immunoglobulin D-positive CD27(+) (IgM(+)IgD(+)CD27(+)) "memory" B cells carrying a mutated immunoglobulin receptor. By means of phenotypic analysis, complementarity-determining region 3 (CDR3) spectratyping during a T-independent response, and gene-expression profiling of the different blood and splenic B-cell subsets, we show here that blood IgM(+)IgD(+)CD27(+) cells correspond to circulating splenic marginal zone B cells. Furthermore, analysis of this peripheral subset in healthy children younger than 2 years shows that these B cells develop and mutate their immunoglobulin receptor during ontogeny, prior to their differentiation into T-independent antigen-responsive cells. It is therefore proposed that these IgM(+)IgD(+)CD27(+) B cells provide the splenic marginal zone with a diversified and protective preimmune repertoire in charge of the responses against encapsulated bacteria.
Source: Blood
Authors: S. Weller, Moritz C Braun, Bruce K Tan, Andreas Rosenwald, Corinne Cordier, Mary Ellen Conley, Alessandro Plebani, Dinakhanta S Kumararatne, Damien Bonnet, Olivier Tournilhac, Gil Tchernia, Birte Steiniger, Louis M Staudt, Jean-Laurent Casanova, Claude-Agnès Reynaud, Jean-Claude Weill
Institutions: Hôpital Necker-Enfants Malades, National Institutes of Health, St. Jude Children's Research Hospital, Inserm, Philipps University of Marburg, Institut Necker Enfants Malades, Assistance Publique – Hôpitaux de Paris, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Centre Hospitalier Universitaire de Clermont-Ferrand, National Cancer Institute, Addenbrooke's Hospital, Bicêtre Hospital, University of Brescia
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2163206714