Work

Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

Year: 2006

Type: article

Abstract: Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0607822103

Authors: Pamela Maher, Tatsuhiro Akaishi, Kazuho Abe

Institutions: Salk Institute for Biological Studies, Musashino University

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministry of Education, Culture, Sports, Science and Technology, U.S. Public Health Service, National Institute on Aging, National Institute of Neurological Disorders and Stroke