Work

Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture

Year: 2007

Type: article

Abstract: We perform Monte Carlo simulations to show that the dual-axes (DA) confocal architecture has superior rejection of multiply scattered photons in tissue to that of single axis. As a result, the DA configuration provides improved signal-to-noise ratio and dynamic range, and thus is sensitive to ballistic photons from deeper within tissue, features that are particularly useful for performing vertical cross-sectional reflectance images in tissue.

Source: Optics Letters

DOI: 10.1364/ol.32.001674

Authors: Larry K. Wong, Michael J. Mandella, Gordon S. Kino, Thomas D. Wang

Institution: Stanford University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1784970113, G2848884011, G5043425204, G5298105158