Work

A Dendritic Thioester Hydrogel Based on Thiol–Thioester Exchange as a Dissolvable Sealant System for Wound Closure

Year: 2013

Type: article

Abstract: Washable wound dressing: A dissolvable dendritic thioester hydrogel for wound closure has been developed. The hydrogel sealant adheres strongly to tissues, closes an ex vivo vein puncture, and withstands high pressures placed on a wound. This material can be washed off upon exposure to thiolates because a thiol–thioester exchange takes place, and gradual wound re-exposure may be achieved during surgical care.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201308007

Authors: Cynthia Ghobril, Kristie Charoen, Edward K. Rodriguez, Ara Nazarian, Mark W. Grinstaff

Institutions: Boston University, Beth Israel Deaconess Medical Center

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering

Award: A Portable Wound Hemostasis System Using a Hydrogel Polymeric Foam