Work

Phorbol ester induces c-sis gene transcription in stem cell line K-562.

Year: 1986

Type: article

Abstract: The phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induced megakaryoblastic differentiation and c-sis expression in the human hematopoietic stem cell line K-562. This induction occurred at the transcriptional level, as determined by a nuclear runoff transcriptional assay, and was not a generalized effect of TPA, since the treatment of other hematopoietic cell lines and normal peripheral blood lymphocytes with TPA did not result in the appearance of c-sis mRNA.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.6.5.1847

Authors: O R Colamonici, J B Trepel, C A Vidal, L M Neckers

Institutions: Walter Reed National Military Medical Center, National Cancer Institute, National Institutes of Health

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2163734664

FWCI: 4.421

Cites: 28

Cited by: 112

Related to: 10