Year: 2011
Type: review
Abstract: Over the course of the last half-century, we have gleaned much about the developmental biology of the pancreas and in particular the insulinproducing b-cell, the autoimmune destruction of which results in type 1 diabetes. Deciphering the mechanisms driving b-cell neogenesis in vivo holds great allure, in large part because of the potential therapeutic applications that stand to be gained. The field of pancreas development was arguably established by such scientists as Rutter, Grobstein, Wessells, and Cohen in the 1960s. Their seminal studies were the first to demonstrate the significance of the mesenchyme in supporting development of the pancreas or indeed any organ. Their work was further extended by Teitelman and colleagues who did much to characterize pancreatic differentiation
Source: Diabetes
DOI: 10.2337/db10-1068
Authors: Philip A. Seymour, Maike Sander
Institution: University of California San Diego
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2163737694