Work

Pathophysiological Manifestations in Mice Exposed to Anthrax Lethal Toxin

Year: 2005

Type: article

Abstract: Pathophysiological changes associated with anthrax lethal toxin included loss of plasma proteins, decreased platelet count, slower clotting times, fibrin deposits in tissue sections, and gross and histopathological evidence of hemorrhage. These findings suggest that blood vessel leakage and hemorrhage lead to disseminating intravascular coagulation and/or circulatory shock as an underlying pathophysiological mechanism.

Source: Infection and Immunity

Authors: Nathan C. Culley, David M. Pinson, Anuradha Chakrabarty, Matthew S. Mayo, Steven M. LeVine

Institution: University of Kansas Medical Center

Language: English

Topic: Bacillus and Francisella bacterial research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases

Award: G120392459