Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy
Year: 2010
Type: review
Abstract: The use of stem cells for tissue regeneration and repair is advancing both at the bench and bedside. Stem cells isolated from bone marrow are currently being tested for their therapeutic potential in a variety of clinical conditions including cardiovascular injury, kidney failure, cancer, and neurological and bone disorders. Despite the advantages, stem cell therapy is still limited by low survival, engraftment, and homing to damage area as well as inefficiencies in differentiating into fully functional tissues. Genetic engineering of mesenchymal stem cells is being explored as a means to circumvent some of these problems. This review presents the current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction. Advancements in other disease areas are also discussed.
Source: Human Gene Therapy
DOI: 10.1089/hum.2010.165
Institutions: Duke Medical Center, Duke University Health System
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G108157200, G1651367797, G2811218247, Gene Therapy for Long-Term Myocardial Protection, Renin Gene Expression in Cardiovascular Regulation: Mechanisms of JG Hyperplasia, Genetically Altered Mesenchymal Stem Cell; Paracrine Effect on Neovascularization, Sfrp2 and Cardiac Progenitor Cells in Regenerative Response to Ischemic Injury
OpenAlex ID: W2163899718