Work

Systems-Level Analysis of Innate Immunity

Year: 2014

Type: review

Abstract: Systems-level analysis of biological processes strives to comprehensively and quantitatively evaluate the interactions between the relevant molecular components over time, thereby enabling development of models that can be employed to ultimately predict behavior. Rapid development in measurement technologies (omics), when combined with the accessible nature of the cellular constituents themselves, is allowing the field of innate immunity to take significant strides toward this lofty goal. In this review, we survey exciting results derived from systems biology analyses of the immune system, ranging from gene regulatory networks to influenza pathogenesis and systems vaccinology.

Source: Annual Review of Immunology

DOI: 10.1146/annurev-immunol-032713-120254

Authors: Daniel E. Zak, Vincent C. Tam, Alan Aderem

Institution: Center for Infectious Disease Research

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Bill and Melinda Gates Foundation, National Institutes of Health, National Institute of Allergy and Infectious Diseases