Year: 2008
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: The purpose of this study was to examine the association of the alpha-actinin-3 (ACTN3) R577X polymorphism on muscle function and physical performance in older adults. METHODS: We measured knee extensor torque, midthigh muscle cross-sectional area, muscle quality, short physical performance battery score, and 400-meter walk time at baseline and after 5 years in white older adults aged 70-79 years in the Health, Aging and Body Composition Study cohort (n = 1367). Incident persistent lower extremity limitation (PLL) over 5 years was additionally assessed. We also examined white men in the Osteoporotic Fractures in Men Study, a longitudinal, observational cohort (n = 1152) of men 65 years old or older as a validation cohort for certain phenotypes. RESULTS: There were no significant differences between genotype groups in men or women for adjusted baseline phenotypes. Male X-homozygotes had a significantly greater adjusted 5-year increase in their 400-meter walk time compared to R-homozygotes and heterozygotes (p =.03). In women, X-homozygotes had a approximately 35% greater risk of incident PLL compared to R-homozygotes (hazard ratio = 0.65, 95% confidence interval = 0.44-0.94). There were no other significant associations between any of the phenotypes and ACTN3 genotype with aging in either cohort. CONCLUSIONS: The ACTN3 polymorphism may influence declines in certain measures of physical performance with aging in older white adults, based on longitudinal assessments. However, the influence of the ACTN3 R577X polymorphism does not appear to have a strong effect on skeletal muscle-related phenotypes based on the strength and consistency of the associations and lack of replication with regard to specific phenotypes.
Institutions: University of Pittsburgh, University of Rhode Island, Veterans Health Administration, Minneapolis VA Medical Center, National Institutes of Health, National Institute on Aging, University of Florida, University of California, San Francisco, University of Tennessee Health Science Center, University of Memphis, University of Maryland, College Park
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Awards: G1068966504, Genetic Epidemiology of Musculoskeletal Aging, G1343274610, G1352229255, DYNAMICS OF HEALTH,AGING, AND BODY COMPOSITION, G1613471689, G1852751850, G1922810624, Osteoporotic Fractures in Men, G197803718, DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION, G2260233006, G2576967755, G2736147164, Bone Strength Phenotypes in men: Genes and Environment, G2961663205, G3048769713, G3049017749, HEALTH ABC--COORDINATING UNIT, G321186775, G3327847537, Genetic Epidemiology of Aging Skeletal Muscle, G3664726445, Osteoporotic Fractures in Men - MrOS Renewal, G3990106893, Osteoporotic Fractures in Men, G4426619567, G5046588511, G5246217528, G5665886026, G5688239834, G5855802124, G5909482378, G659495149, G6790992111, G6821916345, G682487154, G7004081433, G7058527481, G7078612884, G7200248429, G7589654153, G7771580635, G801436702, G8151528796, G8162531676, G8243955340, G870807107, G9000021615, G9000033828, G9000058914, G9000064213, G9000085452, G9000111449, G9000121640, G9000291326, University of Florida Older Americans Independence Center (OAIC), Training in the Epidemiology of Aging, G945304896, G972017601
OpenAlex ID: W2164099708