Work

Fluorochrome‐Functionalized Magnetic Nanoparticles for High‐Sensitivity Monitoring of the Polymerase Chain Reaction by Magnetic Resonance

Year: 2012

Type: article

Abstract: Easy to find: magnetic nanoparticles bearing fluorochromes (red) that intercalate with DNA (green) form microaggregates with DNA generated by the polymerase chain reaction (PCR). These aggregates can be detected at low cycle numbers by magnetic resonance (MR).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201201661

Authors: David Alcantara, Yanyan Guo, Hushan Yuan, Craig J. Goergen, Howard H. Chen, Hoonsung Cho, David E. Sosnovik, Lee Josephson

Institutions: Universidad de Zaragoza, Massachusetts General Hospital, Instituto de Nanociencia y Materiales de Aragón, Athinoula A. Martinos Center for Biomedical Imaging

Language: English

Topic: Characterization and Applications of Magnetic Nanoparticles

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources

Awards: Reagents for the Design of Targeted Multifunctional Nanomaterials, Multimodal Vital Fluorochromes for Imaging, Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and Autophagy, Center for Functional Imaging Technologies, Interdepartmental Neuroscience Center, Upgrade for Biospec Console and accessories for the 9.4T/20cm Magnet

OpenAlex ID: W2164154949

FWCI: 2.368

Cites: 29

Cited by: 28

Related to: 10