Year: 2007
Type: review
Abstract: Craniosynostosis is a common malformation occurring in 3-5 per 10,000 live births. Most often craniosynostosis occurs as an isolated (i.e. non-syndromic) anomaly. Non-syndromic craniosynostosis (NSC) is a clinically and genetically heterogeneous condition that has the characteristics of a multifactorial trait. It is believed that each sutural synostosis (e.g. sagittal, coronal) represents a different disease. Significant progress has been made in understanding the clinical and molecular aspects of monogenic syndromic craniosynostosis. However, the phenotypic characterization of NSC is incomplete and its causes remain unknown. This review summarizes the available knowledge on NSC and presents a systematic approach aimed at the identification of genetic and non-genetic factors contributing to the risk of this common craniofacial defect.
Author: SA Boyadjiev
Institution: University of California, Davis
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: University of Missouri, Washington University in St. Louis, University of Washington, Johns Hopkins University, University of Oklahoma, Deutsches Krebsforschungszentrum, Children's Miracle Network Hospitals, University of Oxford, Universität zu Köln, National Institutes of Health, University of California, Davis, University of California, Irvine, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Center for Research Resources
OpenAlex ID: W2164204351