Work

Insight into DEG/ENaC Channel Gating from Genetics and Structure

Year: 2012

Type: review

Abstract: The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans proteins that form mechanosensitive channels in touch and pain receptors. For more than a decade, the research community has used mutagenesis to identify motifs that regulate gating. This review integrates insight derived from unbiased in vivo mutagenesis screens with recent crystal structures to develop new models for activation of mechanically gated DEGs.

Source: Physiology

DOI: 10.1152/physiol.00006.2012

Authors: Amy L. Eastwood, Miriam B. Goodman

Institution: Stanford University

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering

Awards: Force Clamp Systems for Evaluation of Mechanotransduction, Investigating the Molecular Basis of Mechanotransduction Channel Gating, Molecular Basis of Sensory Transduction in C. elegans