Work

Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain

Year: 2010

Type: article

Abstract: BACKGROUND: In an effort to identify genes that specify the mammalian forebrain, we used a comparative approach to identify mouse homologs of transcription factors expressed in developing Caenorhabditis elegans GABAergic neurons. A cell-specific microarray profiling study revealed a set of transcription factors that are highly expressed in embryonic C. elegans GABAergic neurons. RESULTS: Bioinformatic analyses identified mouse protein homologs of these selected transcripts and their expression pattern was mapped in the mouse embryonic forebrain by in situ hybridization. A review of human homologs indicates several of these genes are potential candidates in neurodevelopmental disorders. CONCLUSIONS: Our comparative approach has revealed several novel candidates that may serve as future targets for studies of mammalian forebrain development.

Source: Neural Development

DOI: 10.1186/1749-8104-5-32

Authors: Elizabeth AD Hammock, Kathie L Eagleson, Susan Barlow, Laurie R Earls, David M Miller, Pat Levitt

Institutions: Vanderbilt University, University of Southern California, St. Jude Children's Research Hospital

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,890