Work

Human Regulatory Gene for Inducible Tyrosine Aminotransferase in Rat-Human Hybrids

Year: 1973

Type: article

Abstract: The inducibility of tyrosine aminotransferase (EC 2.6.1.5) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8) and, therefore, can be assigned to the X chromosome.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.70.4.1268

Authors: Carlo M. Croce, Gerald Litwack, Hilary Koprowski

Institutions: The Wistar Institute, Temple University

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2164260564

FWCI: 9.36

Cites: 19

Cited by: 66

Related to: 10