Work

Trifluoromethyl ethers – synthesis and properties of an unusual substituent

Year: 2008

Type: article

Abstract: After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.4.13

Authors: Frédéric R Leroux, Baptiste Manteau, Jean-Pierre Vors, Sergiy Pazenok

Institutions: Centre National de la Recherche Scientifique, Bayer (France), Bayer (Germany)

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Centre National de la Recherche Scientifique, Bayer CropScience

OpenAlex ID: W2164327964