Year: 2005
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Gefitinib is an oral agent that inhibits the tyrosine kinase of epidermal growth factor receptor (EGFR), which had antitumor activity in patients with previously treated non-small cell lung cancer (NSCLC). We analyzed the efficacy, toxicity and overall survival time of gefitinib treatment in patients with NSCLC. PATIENTS AND METHODS: One hundred and twenty-two patients with NSCLC, who received gefitinib between 2002 and 2004 in our institutes, were evaluated retrospectively. RESULTS: The objective response rate was 24.6%. The variables identified as significant in univariate analysis included gender and smoking habit. The median overall survival time was 14.4 months. Significant variables associated with improved survival included good performance status (PS), female, adenocarcinoma and never smoked status, while never smoked status and good PS were independent prognostic factors in multivariate analysis. Four patients (3.3%) developed interstitial pneumonitis associated with gefitinib. CONCLUSION: Gefitinib showed favorable anti-tumor activity in females, never smokers and adenocarcinoma.
Source: PubMed
Authors: Jun Konishi, Koichi Yamazaki, Ichiro Kinoshita, Hiroshi Isobe, Shigeaki Ogura, Satoko Sekine, Takashi Ishida, Riou Takashima, Megumi Nakadate, Shyu Nishikawa, Takeshi Hattori, Hajime Asahina, Mikado Imura, Eiki Kikuchi, Junko Kikuchi, Naofumi Shinagawa, Hiroshi Yokouchi, Mitsuru Munakata, Hirotoshi Dosaka-Akita, Masaharu Nishimura
Institution: Hokkaido University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2164337291