Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation
Year: 2009
Type: review
Abstract: The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events and they can disrupt expression of genes. Determination of which adduct is responsible for each of these biological endpoints is difficult, but this task has been accomplished for some carcinogenic DNA-damaging agents. Here, we describe the respective contributions of specific DNA lesions to the biological effects of low molecular weight alkylating agents.
Source: Carcinogenesis
Authors: N. Shrivastav, D. Li, J. M. Essigmann
Institution: Massachusetts Institute of Technology
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Intra- and Extra-Chromosomal Probes for Mutagenesis by Carcinogens, G325791324, MIT Center for Environmental Health Sciences, Mechanistic Comparison of Cisplatin with Synthetic DNA Repair-Shielding Anticance, Endogenous Nitrite Carcinogenesis in Man, Intra and Extra-Chromosomal Probes for Mutagenesis by Carcinogens
OpenAlex ID: W2164390042