Work

No association of candidate genes with cannabis use in a large sample of Australian twin families

Year: 2011

Type: article

Study design: Observational Study

Abstract: While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies.

Source: Addiction Biology

DOI: 10.1111/j.1369-1600.2011.00320.x

Authors: Karin J. H. Verweij, Brendan P. Zietsch, Jimmy Z. Liu, Sarah E. Medland, Michael T. Lynskey, Pamela A. F. Madden, Arpana Agrawal, Grant W. Montgomery, Andrew C. Heath, Nicholas G. Martin

Institutions: The University of Queensland, QIMR Berghofer Medical Research Institute, Washington University in St. Louis

Language: English

Topic: Cannabis and Cannabinoid Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Institute on Drug Abuse

Awards: G1207839733, The Genetics of Vulnerability to Nicotine Addictions, G1398898637, G1583026501, G16286648, G2268797580, G2561471519, G3548961933, G3619332945, G412057792, G4471409110, Molecular Epidemiology of Alcoholism 1: Candidate Gene, G5113003846, G6129226368, G6837203315, G8471761114, PERSISTENCE AND CHANGE IN DRINKING HABITS--TWIN STUDY

OpenAlex ID: W2164413591

FWCI: 1.668

Cites: 8

Cited by: 23

Related to: 10