Work

Computational study of an augmented minimal model for glycaemia control

Year: 2008

Type: conference-paper

Abstract: In this paper we introduce a new model structure for the metabolic effects of intravenous insulin on blood glucose in man and derive its parameter values from the widely used model of Sorensen. The proposed model attempts to combine the advantages of the existing comprehensive and minimal models. Validation of the new model is done through deriving equivalent nonparametric nonlinear models in the form of Principal Dynamic Modes. We show that the new structure can represent the insulin-glucose dynamics of healthy subjects as well as Type 1 and Type 2 diabetics, with appropriate adjustment in its parameters.

Source: Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

DOI: 10.1109/iembs.2008.4650446

Authors: Mihalis G. Markakis, Georgios D. Mitsis, Vasilis Z. Marmarelis

Institutions: University of Southern California, Massachusetts Institute of Technology, National Technical University of Athens

Language: English

Topic: Diabetes Management and Research

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering