Work

Review on role of Myeloid-derived Suppressor cells in regulation of immune system

Year: 2013

Type: article

Abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expands during cancer, inflammation and infection, and together with regulatory T cells (Tregs) have a remarkable ability to suppress immune responses. The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. Limited data are available on MDSC in humans. Suppressor activity has been associated with high arginase 1 and iNOS activity as well as ROS production by MDSC. MDSCs regulate both acquired and innate immunity by direct or indirect pathways. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.

Source: Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Māzandarān/Journal of Mazandaran University of Medical Sciences

Authors: Hamideh Mesali, Mojtaba Shadman, Mohsen Tehrani, Abolghasem Ajami

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2164464944

FWCI:

Cites: 69

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Related to: 10