DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts
Year: 2015
Type: article
Study design: Observational Study
Abstract: The first epigenome-wide association study of BMI identified DNA methylation at an HIF3A locus associated with BMI. We tested the hypothesis that DNA methylation variants are associated with BMI according to intake of B vitamins. In two large cohorts, we found significant interactions between the DNA methylation-associated HIF3A single nucleotide polymorphism (SNP) rs3826795 and intake of B vitamins on 10-year changes in BMI. The association between rs3826795 and BMI changes consistently increased across the tertiles of total vitamin B2 and B12 intake (all P for interaction <0.01). The differences in the BMI changes per increment of minor allele were -0.10 (SE 0.06), -0.01 (SE 0.06), and 0.12 (SE 0.07) within subgroups defined by increasing tertiles of total vitamin B2 intake and -0.10 (SE 0.06), -0.01 (SE 0.06), and 0.10 (SE 0.07) within subgroups defined by increasing tertiles of total vitamin B12 intake. In two independent cohorts, a DNA methylation variant in HIF3A was associated with BMI changes through interactions with total or supplemental vitamin B2, vitamin B12, and folate. These findings suggest a potential causal relation between DNA methylation and adiposity.
Source: Diabetes
DOI: 10.2337/db15-0264
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: American Heart Association, Damon Runyon Cancer Research Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Eye Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G1293366060, Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut Microbiota, Obesity Genes, Energy Regulation in Response to Weight-Loss Diets, G150102659, G151562090, G1543486331, G1717613936, G1861573265, Genetic Markers of CHD in Type 2 Diabetes, Biochemical Markers in the nurses' Health Study Cohort, Genome-Wide Association Study of Endometrial Cancer, G2750880407, Genes and Environment Initiatives in Type 2 Diabetes, Gene-Environment Interactions in Glaucoma, Biochemical and Genetic Markers of Type 2 Diabetes Risk, G3059241284, G3319515530, Boston Nutrition Obesity Research Center, G3875417561, Dietary and Hormonal Determinants of Cancer in Women, Genes and Environment Initiative in Glaucoma, Genetics of Coronary Artery Disease in Type 2 Diabetes, G459566519, G4885623132, G518464440, G5433162186, G5511382046, The Pathobiology of Nephrolithiasis, Harvard Transdisciplinary Research in Energetics and Cancer Center, Epidemiology of Precursors to Type 2 Diabetes, Genome-wide interactions with diet patterns on long-term weight change, G5869775930, G588599347, Mentored Patient-Oriented Research in Digestive Diseases, G6812933845, Molecular pathological epidemiology of colorectal cancer, Prospective Studies of Diet and Cancer in Men and Women, G7552017953, Biochemical Markers in the Nurses? Health Study Cohort, G772621625, G83951392, G9000028950, G9000190097, RISK FACTORS FOR CVD IN WOMEN, Risk Factors for Ischemic Stroke in Women, G985071772
OpenAlex ID: W2164468750