Work

Hematopoietic Stem Cell Transplantation (HSCT) using Umbilical Cord Blood units (UCB) not depleted of red blood cells prior to cryopreservation

Year: 2006

Type: article

Abstract: UCB is a promising source for HSCT; however, limiting cell dose has hampered its widespread use. The red cell depletion (RCD) techniques that are widely used incur significant nucleated cell loss after processing. One method of minimizing cell loss during processing is to deplete plasma (PD) but not red blood cells. Average loss of less than 0.1% nucleated cells was found in the discarded plasma fraction after PD UCB processing (n = 27). Eighteen thousand racially diverse PD UCB units are now available on stem cell registries; however, clinical outcome for HSCT using PD UCB products is unavailable.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.313