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Coupling of Human Circadian and Cell Cycles by the Timeless Protein

Year: 2005
Type: article
Abstract: The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability and appears to be required for the maintenance of a robust circadian rhythm as well. We have found that the human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
DOI: 10.1128/mcb.25.8.3109-3116.2005
Language: English
Open Access status: green
Funders: University of Southern California, Florida State University, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences
Awards: DNA Excision Repair and DNA Damage Checkpoints, ROLE OF CRYPTOCHROME IN THE CIRCADIAN CLOCK AND DNA DAMAGE RESPONSES, G342085443, STRUCTURE/FUNCTION OF DNA PHOTOLYASE, G2 Checkpoint Function in Human Fibroblasts, G9000020968, G9000237067, UNC Center for Environmental Health and Susceptibility, Cancer Center Support Grant
OpenAlex ID: W2164585152
FWCI: 5.725
Cites: 43
Cited by: 313
Related to: 10