Current progress in our understanding of cholestasis and chronic cholestatic disorders
Year: 2007
Type: article
Abstract: George V. Papatheodoridis, MD, 1 Ath. Diakou str., 152 35 Vrilissia, Greece, Tel: 00301-6130485, Fax: 00301-6138036, e-mail: [email protected] Cholestasis results from any cause that impairs bile acid transport from the liver to the intestine. The formation of bile as well as the biliary secretion of many endogenous and exogenous substances are essential functions of the liver. The secretion of bile depends on the function of several transporters found on the membranes of hepatocytes and cholangiocytes. Many of these transporters have now been cloned, several molecular defects have been identified and associated with various forms of cholestatic diseases. At the histological level, chronic cholestastic diseases result from inflammatory and destructive processes that may involve the intrahepatic and/ or extrahepatic biliary tree or from developmental defects. Most chronic cholestatic diseases may progress towards biliary cirrhosis, portal hypertension, and eventually hepatocellular insufficiency. Chronic cholestatic conditions can be separated into those presented mainly in infancy and childhood and those presented first in adulthood (Table 1). This review summarizes some of the recent developments in our understanding of the hepatobiliary transport as well as of the pathogenesis and classification of chronic cholestatic disorders.
Source: Annals of Gastroenterology
Author: George Papatheodoridis
Institution: National and Kapodistrian University of Athens
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2164603619