Work

Synthesis of DNA Interstrand Cross‐Links Using a Photocaged Nucleobase

Year: 2012

Type: article

Abstract: The missing linking: BCNU is a chemotherapy drug that generates an ethylene bridge between N(1) of deoxyguanosine and N(3) of deoxycytidine. No synthesis of a DNA containing this moiety has been reported until now. A new strategy uses a photocaged nucleobase that, when released, generates a highly reactive intermediate which cross-links the opposing DNA strand in a manner analogous to BCNU.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201108018

Authors: Sarah Hentschel, Jawad Alzeer, Todor Angelov, Orlando D. Schärer, Nathan W. Luedtke

Institutions: University of Zurich, Palestine Polytechnic University, ETH Zurich, Institute of Food, Nutrition, and Health, Stony Brook University

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2164668748

FWCI: 1.51

Cites: 38

Cited by: 33

Related to: 10