Year: 2010
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Inflammation and chronic kidney disease (CKD) are both associated with cardiovascular disease (CVD). Whether inflammatory biomarkers are associated with kidney function and albuminuria after accounting for traditional CVD risk factors is not completely understood. METHODS: The sample comprised Framingham Offspring cohort participants (n = 3294, mean age 61, 53% women) who attended the seventh examination cycle (1998-2001). Inflammatory biomarkers [C-reactive protein (CRP), tumour necrosis factor (TNF)-alpha, interleukin-6, TNF receptor 2 (TNFR2), intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), P-selectin, CD-40 ligand, osteoprotegerin, urinary isoprostanes, myeloperoxidase and fibrinogen] were measured on fasting blood samples. Serum creatinine-based estimated glomerular filtration rate (eGFR) and serum cystatin C concentration were used to assess kidney function. Urinary albumin-to-creatinine ratio (UACR) was used to assess albuminuria. Linear or logistic regression was used to test associations between biomarkers and kidney measures. RESULTS: Chronic kidney disease (CKD), defined as eGFR < 59/64 mL/min/1.73 m(2) in women/men, was present in 8.8% (n = 291) of participants. TNF-alpha, interleukin-6, TNFR2, MCP-1, osteoprotegerin, myeloperoxidase and fibrinogen were higher among individuals with CKD; all biomarkers except for urinary isoprostanes were elevated in higher cystatin C quartiles; and TNF-alpha, interleukin-6, TNFR2, ICAM-1 and osteoprotegerin were elevated in higher UACR quartiles-all assessed after multivariable adjustment. Almost 6% and 17% of variability in TNFR2 were explained by CKD status and higher cystatin C quartiles, respectively. CONCLUSIONS: Biomarkers of inflammation are associated with kidney function and albuminuria. In particular, substantial variability in soluble TNFR2 is explained by CKD and cystatin C.
DOI: 10.1093/ndt/gfq471
Institutions: Tufts University, Tufts Medical Center, Boston University, Framingham Heart Study, Beth Israel Deaconess Medical Center, Harvard University, Massachusetts General Hospital, UMass Memorial Health Care, University of Massachusetts Chan Medical School, UMass Memorial Medical Center, Brigham and Women's Hospital
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: GROWTH RELATED GENES IN VASCULAR SMOOTH MUSCLE, G250621538, G3042145041, G3736397804, Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study, G5164707915, INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM, Epidemiology of Precursors to Type 2 Diabetes, Framingham: Inflammation, Genes & Cardiovascular Disease, The Framingham Heart Study, G6852737108, G816297423
OpenAlex ID: W2164697745