The Proteasome, a Novel Protease Regulated by Multiple Mechanisms
Year: 1999
Type: review
Abstract: Investigators have long recognized the potential importance of protein degradation as a mechanism for regulating levels of cellular proteins (1-3). Nevertheless, only recent studies of the ubiquitin-proteasome pathway have shown how extensively proteolysis is involved in the regulation of crucial cellular processes such as: progression of the cell cycle, oncogenesis, transcription, development, growth and atrophy of developed tissues, flux of substrates through metabolic pathways, selective elimination of abnormal proteins, and antigen processing.
Source: Journal of Biological Chemistry
Authors: George N. DeMartino, Clive A. Slaughter
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W2164710551