Work

Enlargement of choroid plexus in complex regional pain syndrome

Year: 2015

Type: article

Abstract: The choroid plexus, located in brain ventricles, has received surprisingly little attention in clinical neuroscience. In morphometric brain analysis, we serendipitously found a 21% increase in choroid plexus volume in 12 patients suffering from complex regional pain syndrome (CRPS) compared with age- and gender-matched healthy subjects. No enlargement was observed in a group of 8 patients suffering from chronic pain of other etiologies. Our findings suggest involvement of the choroid plexus in the pathogenesis of CRPS. Since the choroid plexus can mediate interaction between peripheral and brain inflammation, our findings pinpoint the choroid plexus as an important target for future research of central pain mechanisms.

Source: Scientific Reports

DOI: 10.1038/srep14329

Authors: Guangyu Zhou, Jaakko Hotta, Maria K. Lehtinen, Nina Forss, Riitta Hari

Institutions: Aalto University, University of Helsinki, Helsinki University Hospital, Boston Children's Hospital, Harvard University

Language: English

Topic: Pain Management and Treatment

Subfield: Anesthesiology and Pain Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690