Work

Pre-Hematopoietic Cell Transplant (HCT) Disease Status and Early Post-HCT Bone Marrow (BM) Chimerism Remain Predictors of Leukemia Relapse in Children Who Receive Preemptive Post-HCT Immunomodulatory Therapy (IT)

Year: 2014

Type: article

Abstract: In 2009, we initiated a prospective study of chimerism-based preemptive IT consisting of fast withdrawal of immunosuppression (FWI) and donor lymphocyte infusions (DLI) in children receiving HCT for leukemia. We enrolled 43 patients. Donors and stem cell sources included matched related (49%), matched unrelated (30%) and mismatched unrelated donors (21%) of BM (53%) and peripheral blood (PB) (47%). Chimerism analyses on whole PB and BM and subsets were done using a semi-quantitative PCR-based method (1% sensitivity), on day 32.5±SD8 (PB) and day38±10 (BM).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.102