Work

Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase.

Year: 1995

Type: article

Abstract: We characterized 18 genes from Caenorhabditis elegans that, when mutated, confer recessive resistance to inhibitors of acetylcholinesterase. These include previously described genes as well as newly identified genes; they encode essential as well as nonessential functions. In the absence of acetylcholinesterase inhibitors, the different mutants display a wide range of behavioral deficits, from mild uncoordination to almost complete paralysis. Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions.

Source: Genetics

DOI: 10.1093/genetics/140.2.527

Authors: M Nguyen, A Alfonso, C D Johnson, J B Rand

Institution: Oklahoma Medical Research Foundation

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: Muscular Dystrophy Association, Oklahoma Center for the Advancement of Science and Technology, National Institutes of Health, National Center for Research Resources

OpenAlex ID: W2164959082

FWCI: 1.191

Cites: 21

Cited by: 211

Related to: 9