Common occurrence of monoclonal B‐cell lymphocytosis among members of high‐risk CLL families
Year: 2010
Type: article
Study design: Observational Study
Abstract: Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic haematological condition characterized by low absolute levels of B-cell clones with a surface immunophenotype similar to that of chronic lymphocytic leukaemia (CLL). In the general population, MBL increases with age with a prevalence of 5-9% in individuals over age 60 years. It has been reported to be higher among first-degree relatives from CLL families. We report results of multi-parameter flow cytometry among 505 first-degree relatives with no personal history of lymphoproliferative disease from 140 families having at least two cases of CLL. Seventeen percent of relatives had MBL. Age was the most important determinant where the probability for developing MBL by age 90 years was 61%. MBL clustered in certain families but clustering was independent of the number of known CLL cases in a family. As is the case with CLL, males had a significantly higher risk for MBL than did females (P = 0·04). MBL patients had significantly higher mean absolute lymphocyte counts (2·4 × 10(9) /l) and B-cell counts (0·53 × 10(9) /l) than those with a normal B-cell immuno-phenotype. Our findings show that MBL occurs at a very high rate in high risk CLL families. Both the age and gender distribution of MBL are parallel to CLL, implying a shared inherited risk.
Source: British Journal of Haematology
Authors: Lynn R. Goldin, Mark C. Lanasa, Susan L. Slager, James R. Cerhan, Celine M. Vachon, Sara S. Strom, Nicola J. Camp, Logan G. Spector, Jose F. Leis, Vicki A. Morrison, Martha Glenn, Kari G. Rabe, Sara J. Achenbach, Sallie D. Algood, Fatima Abbasi, Laura Fontaine, Michelle Yau, Laura Z. Rassenti, Neil E. Kay, Timothy G. Call, Curtis A. Hanson, J. Brice Weinberg, Gerald E. Marti, Neil E. Caporaso
Institutions: National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Duke Medical Center, Mayo Clinic, The University of Texas MD Anderson Cancer Center, University of Utah, University of Minnesota, Mayo Clinic in Arizona, Minneapolis VA Medical Center, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Westat (United States), University of California San Diego, Moores Cancer Center, Durham VA Medical Center
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2165012325