Work

Novel, Orally Effective Cyanide Antidotes

Year: 2007

Type: article

Abstract: A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm7011497

Authors: Herbert T. Nagasawa, David J. W. Goon, Daune L. Crankshaw, Robert Vince, Steven E. Patterson

Institution: University of Minnesota

Language: English

Topic: Cassava research and cyanide

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke