Work

The Clearance of Cyclosporine by Hemodialysis

Year: 1984

Type: article

Abstract: The pharmacokinetics of cyclosporine were studied in five liver transplant patients when they were on and off hemodialysis. There was no significant difference in the blood clearance of cyclosporine between these two periods. Less than 1 per cent of the dose of cyclosporine was recovered in the dialysate. The mean dialysis clearance was less than 1 ml/min. This represents less than 1 per cent of the total blood clearance of cyclosporine. Dosage alterations of cyclosporine during or after hemodialysis do not appear to be necessary.

Source: The Journal of Clinical Pharmacology

DOI: 10.1002/j.1552-4604.1984.tb02763.x

Authors: RAMAN VENKATARAMANAN, RICHARD J. PTACHCINSKI, GILBERT J. BURCKART, SHIN L. YANG, THOMAS E. STARZL, DAVID H. VAN THEIL

Institution: University of Pittsburgh

Language: English

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health