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Colon perforation during antiangiogenic therapy for malignant glioma

Year: 2008

Type: article

Abstract: Antiangiogenic drugs have emerged as effective treatment options for patients with recurrent malignant gliomas (MGs). Though this class of drugs is generally well tolerated, rare life-threatening complications, including thromboembolism, hemorrhage, and gastrointestinal (GI) perforation, are reported. We describe six cases of GI perforation among 244 glioma patients (2.5%) during treatment with antiangiogenic agents in combination with chemotherapy and corticosteroids. Two patients succumbed to this complication, and the others recovered. Because GI perforation is a life-threatening yet treatable complication, neurooncologists must have a low threshold to consider it in patients on antiangiogenic drug therapy who present with abdominal pain and other GI complaints.

Source: Neuro-Oncology

DOI: 10.1215/15228517-2008-071

Authors: Andrew D. Norden, Jan Drappatz, Abigail Slate Ciampa, Lisa Doherty, Debra Conrad LaFrankie, Santosh Kesari, Patrick Y. Wen

Institutions: Brigham and Women's Hospital, Harvard University, Center for Neuro-Oncology, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2165206907

FWCI: 2.147

Cites: 16

Cited by: 24

Related to: 10