Work

Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination

Year: 2008

Type: review

Abstract: Palladium-catalyzed amination reactions of aryl halides have undergone rapid development in the last 12 years, largely driven by the implementation of new classes of ligands. Biaryl phosphanes have proven to provide especially active catalysts in this context. This Review discusses the application of these catalysts in C-N cross-coupling reactions in the synthesis of heterocycles and pharmaceuticals, in materials science, and in natural product synthesis.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200800497

Authors: David S. Surry, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: CATALYTIC METHODS FOR ORGANIC SYNTHESIS, Late Transition Metal Catalysts for Organic Synthesis