Get started
Work

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

Year: 2000
Type: article
Abstract: The chemokine stromal-derived factor-1 (SDF-1) controls many aspects of stem cell function. Details of its regulation and sites of production are currently unknown. We report that in the bone marrow, SDF-1 is produced mainly by immature osteoblasts and endothelial cells. Conditioning with DNA-damaging agents (ionizing irradiation, cyclophosphamide, and 5-fluorouracil) caused an increase in SDF-1 expression and in CXCR4-dependent homing and repopulation by human stem cells transplanted into NOD/SCID mice. Our findings suggest that immature osteoblasts and endothelial cells control stem cell homing, retention, and repopulation by secreting SDF-1, which also participates in host defense responses to DNA damage.
DOI: 10.1172/jci10329
Authors: Tanya Ponomaryov, Amnon Peled, Isabelle Petit, Russell S. Taichman, Liliana Habler, Judith Sandbank, Fernando Arenzana-Seisdedos, Aude Magerus, Antonio Caruz, Nobutaka Fujii, Arnon Nagler, Meir Lahav, Martin Szyper-Kravitz, Dov Zipori, Tsvee Lapidot
Institutions: Weizmann Institute of Science, University of Michigan, Assaf Harofeh Medical Center, Institut Pasteur, Universidad de Jaén, Kyoto University, Hadassah Medical Center, Meir Medical Center
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: bronze
OpenAlex ID: W2165521277
FWCI: 10.18
Cites: 64
Cited by: 598
Related to: 10