Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis: II. MRI analysis results of a multicenter, randomized, double‐blind, placebo‐controlled trial
Year: 1993
Type: article
Abstract: We performed yearly MRI analyses on 327 of the total 372 patients in a multicenter, randomized, double-blind, placebo-controlled trial of interferon beta-1b (IFNB). Clinical results are presented in the preceding companion paper. Baseline MRI characteristics were the same in all treatment groups. Fifty-two patients at one center formed a cohort for frequent MRIs (one every 6 weeks) for analysis of disease activity. The MRI results support the clinical results in showing a significant reduction in disease activity as measured by numbers of active scans (median 80% reduction, p = 0.0082) and appearance of new lesions. In addition, there was an equally significant reduction in MRI-detected burden of disease in the treatment as compared with placebo groups (mean group difference of 23%, p = 0.001). These results demonstrate that IFNB has made a significant impact on the natural history of MS in these patients.
Source: Neurology
DOI: 10.1212/wnl.43.4.662
Authors: D. W. Paty, D.K.B. Li, the UBC MS/MRI Study Group, the IFNB Multiple Sclerosis Study Group
Institution: University of British Columbia
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2165547142